Alveolar ridge augmentation with the perforated and nonperforated bone grafts.

PURPOSE: Autogenous bones are frequently used because of their lack of antigenicity, but good osteoconductive and osteoinductive properties. This study evaluated the biological behavior of perforated and nonperforated cortical block bone grafts. METHODS: Ten nonsmoking patients who required treatment due to severe resorption of the alveolar process and subsequent implant installation were included in the study. The inclusion criteria was loss of one or more teeth; the presence of atrophy of the alveolar process with the indication of reconstruction procedures to allow rehabilitation with dental implants; and the absence of systemic disease, local infection, or inflammation. The patients were randomly divided into two groups based on whether they received a perforated (inner surface) or nonperforated graft. After a 6-month healing period, a biopsy was performed and osseointegrated implants were installed in the same procedure. RESULTS: Fibrous connective tissue was evident at the interface in patients who received nonperforated grafts. However, full union between the graft and host bed was visible in those who had received a perforated graft. CONCLUSIONS: We found that cortical inner side perforations at donor sites increased the surface area and opened the medullary cavity. Our results indicate an increased rate of graft incorporation in patients who received such perforated grafts.

Neurofibromatose: uma desordem hereditária: relato de caso de ocorrência em mãe e filha / Neurofibromatosis: a hereditary disorder: a case of neurofibromatosis occurring in mother and daughter

A neurofibromatose é uma desordem genética caracterizada pelo aparecimento de neoplasias benignas que acompanham o trajeto do nervo envolvido, alterações cutâneas e, em alguns casos mais raros, lesões gastrintestinais e alterações no sistema nervoso central, com conseqüente retardo mental. Não existe cura para essa desordem, mas existe uma grande quantidade de tratamentos alternativos, como a remoção cirúrgica dos neurofibromas, ou a remoção das manchas café-com-leite com laser. O objetivo deste trabalho é realizar uma revisão de literatura e apresentar um caso de Neurofibromatose com ocorrência em mãe e filha.

Platelet-rich plasma influence on human osteoblasts growth.

OBJECTIVE: The influence of progressively high concentrations of platelet-rich plasma (PRP) on human osteoblast hFOB1.19 proliferation was evaluated. MATERIAL AND METHODS: The PRP was obtained from a human source. Two experiments were conducted. In the first one, PRP was diluted to 50%, 25%, 12.5% and 6.125% (v/v) with culture medium (Modified Eagle's Medium (MEM) : Ham's F12 Medium (HAM-F12%) and 1% antibiotics-antimicotic) supplemented with 10% of fetal bovine serum (FBS). In the second experiment, all conditions were identical except for the absence of FBS in the culture medium. RESULTS: The results of the osteoblast proliferation test were higher when stimulated by the 50% PRP dilution, with or without FBS. A further study is suggested to determine if concentrations above 50% could cause higher rates of osteoblast proliferation. In this study, the results were not statistically different (P<0.05) with 12.5% and 6.125% PRP dilutions. Additionally, it was shown that FBS is not necessary for PRP-mediated induction of osteoblast proliferation. CONCLUSION: This study concluded that PRP promotes osteoblast proliferation and suggested its clinical application to bone graft procedures in implant dentistry.